Scientist I, Biologics Drug Substance Development, Cell Culture Development

Company: AbbVie
Location: San Francisco
Posted on: March 28, 2026

Job Description:

Company Description About AbbVie AbbVie's mission is to discover and deliver innovative medicines and solutions that solve serious health issues today and address the medical challenges of tomorrow. We strive to have a remarkable impact on people's lives across several key therapeutic areas including immunology, oncology and neuroscience - and products and services in our Allergan Aesthetics portfolio. For more information about AbbVie, please visit us at www.abbvie.com . Follow @abbvie on LinkedIn, Facebook , Instagram , X and YouTube. Job Description The Cell Culture Development Group in South San Francisco, CA is seeking a Scientist I to join a talented and collaborative team to develop cell culture processes for GMP applications. In this position, you will perform cell culture process development, scale-up, and technology transfer activities in a well-supported and dynamic environment to help advance novel biotherapeutics into human clinical studies. KEY RESPONSIBILITIES: Perform inoculum expansion and cell bank generation Execute cell culture experiments using Ambr250 and 2L bioreactors Perform pilot scale material generation using 50L, 200L and 500L single use bioreactors Execute small scale and pilot scale depth filtration and centrifugation primary recovery processes Perform tech transfer of Master cell bank generation, cell culture and primary recovery processes to the GMP manufacturing facilities Provide person-in-plant support at the GMP manufacturing facility Perform cell culture experiments to optimize N-1 perfusion processes as well as intensified fed-batch processes Represent the cell culture development group for pipeline projects in cross-functional meetings and collaborate closely with cell line, purification, analytical and formulation development leads to meet project timelines Author and review technical reports, GMP campaign summary reports, and relevant sections in regulatory filings Proactively identify and implement opportunities to optimize platform processes and deepen process understanding Present scientific findings at internal or external conferences Collaborate effectively with colleagues to promote a positive and efficient laboratory environment, and actively contribute ideas to enhance lab workflows and practices Qualifications Required Scientific degree in chemical engineering, bioengineering, biotechnology, or a related field. A minimum of 2 years for M.S. or 5 years for B.S. graduates Proficient in aseptic techniques Experience in developing and executing mammalian suspension cell culture processes in shake flasks, Ambr250 and 2L bioreactors Strong understanding of mammalian cell and molecular biology and cell culture bioprocess engineering concepts Strong attention to detail; active and quick learner; able to change courses quickly as needed, raises the bar and is never satisfied with the status quo; opens to suggestions and embraces the ideas of others; actively builds relationships with others Experience in technical report authoring and reviewing Proficient with Microsoft Office software (Word, Excel, and PowerPoint) and statistical modelling software such as JMP Preferred: Experience in perfusion technology, especially Alternating Tangential flow filtration (ATF) at bench Experience in pilot scale operations including 50L, 200L, 500L Single-use systems, and harvest operations Additional Information Applicable only to applicants applying to a position in any location with pay disclosure requirements under state orlocal law: The compensation range described below is the range of possible base pay compensation that the Companybelieves ingood faith it will pay for this role at the timeofthis posting based on the job grade for this position.Individualcompensation paid within this range will depend on many factors including geographic location,andwemayultimatelypaymore or less than the posted range. This range may bemodifiedin thefuture. We offer a comprehensive package of benefits including paid time off (vacation, holidays, sick),medical/dental/visioninsurance and 401(k) to eligibleemployees. This job is eligible toparticipatein our short-term incentiveprograms. Note: No amount of payis considered to bewages or compensation until such amount is earned, vested, anddeterminable.The amount and availability of anybonus,commission, incentive, benefits, or any other form ofcompensation and benefitsthat are allocable to a particular employeeremainsin the Company's soleandabsolutediscretion unless and until paid andmay bemodifiedat the Companys sole and absolute discretion, consistent withapplicable law. AbbVie is an equal opportunity employer and is committed to operating with integrity, driving innovation, transforming lives and serving our community. Equal Opportunity Employer/Veterans/Disabled. US & Puerto Rico only - to learn more, visit https://www.abbvie.com/join-us/equal-employment-opportunity-employer.html US & Puerto Rico applicants seeking a reasonable accommodation, click here to learn more: https://www.abbvie.com/join-us/reasonable-accommodations.html

Keywords: AbbVie, Union City , Scientist I, Biologics Drug Substance Development, Cell Culture Development, Engineering , San Francisco, California