Scientist 1 Bioconjugation Chemistry
Location: San Rafael
Posted on: June 23, 2025
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Job Description:
Who We Are From research and discovery to post-market clinical
development, our WWRD engine involves all bench and clinical
research and the associated groups that support those endeavors.
Our teams work on developing first-in-class and best-in-class
therapeutics that provide meaningful advances to patients who live
with genetic diseases. Duties Synthesis, optimization, and
high-quality delivery of various polymer, protein/peptide, and
lipidated bioconjugates in support of discovery and development of
novel therapeutics, with an emphasis on oligonucleotides
Development and implementation of new linker chemistries/spacers
and bioconjugation methods for targeted drug delivery Leveraging
appropriate purification and analytical characterization approaches
for QC and validation Collaboration with internal and external
partners for material transfer to support in vitro and in vivo POC
experiments; assemble data packages and maintain quality control
documentation through Benchling for final product delivery.
Effectively partner with cross-functional teams, sharing insights,
troubleshooting issues, and driving science forward from the bench
Serve independently as bioconjugation technical lead and subject
matter expert for internal and external project communications
Perform data analysis, interpret, and present results during
internal and external meetings; attend and participate in
scientific proceedings. Prepare and optimize chemistry SOPs
Participate and present data and share responsibility for project
milestones Skills Extensive experience with different
bioconjugation strategies and optimizations thereof for polymers,
proteins/peptides, lipids, oligonucleotides and other biomolecules
In-depth experience in bioconjugate purification techniques
including various liquid chromatography methods (e.g. RP, IEX, SEC,
HIC, affinity, FPLC) and membrane filtrations (e.g. TFF) Prior
experience in biochemistry techniques and analytical methods such
as SEC-MALs, LCMS, SPR/BLI, ELISA, SDS-PAGE, enzyme activity
assays, etc. Willingness to learn new bioconjugation chemistries or
delivery modalities and work across diverse therapeutic areas to
develop protein therapeutics. Strong analytical mindset and
chemistry problem-solving with creative thinking The position
requires organization skills, attention to detail, self-motivation,
and strong teamwork in a fast-paced setting Education Ph.D. in
Chemical Engineering, Chemical Biology, Chemistry, or related
fields is required; Scientist 1 will have 0-2 years of
industry/post-doc experience relating to drug development Strong
foundation in macromolecular chemistry, bioconjugation, analytical
chemistry and/or chemical biology is strongly desired. A record of
accomplishments/publications in relevant scientific discipline and
some hands-on experience in oligonucleotide delivery is preferred
but not required. Equal Opportunity Employer/Veterans/Disabled An
Equal Opportunity Employer. All qualified applicants will receive
consideration for employment without regard to race, color,
religion, sex, sexual orientation, gender identity, national
origin, or protected veteran status and will not be discriminated
against on the basis of disability.
Keywords: , Union City , Scientist 1 Bioconjugation Chemistry, Science, Research & Development , San Rafael, California
